Well, I'm not him and certainly he can speak for himself, but I can chime in here
I believe he's got 3 monitors. The center looks like a pretty normal window, "the main window".
On either side of the main window he's got dxNothing windows. dxNothing is a Direct3D app I wrote that doesn't actually do anything on its own. This makes it ideal for use as a stand-in, blank "game window" for ISBoxer -- you can place any ISBoxer widgets in them! See
http://isboxer.com/forum/viewtopic.php?f=35&t=1222 for details on setting this up.
In his dxNothing windows he's got
Video FX (<-- that link has all of the information you want and more). I believe I see Overview, HUD/Modules, and Targeting, among other things? I'm no EVE expert
Anyway, this gives you visibility and -- importantly -- efficient use of the space on your monitors. PLUS you can mouse over to ANY of those pieces and interact with what you're looking at with the mouse and keyboard.
Then to do things at the same time in more than one window, commonly in EVE this is done with Broadcasting mode (Shift+Alt+R by default). With most other games we usually prefer to use the keyboard, and use Key Maps to map specific behaviors to specific buttons. Broadcasting mode, conversely, just does exactly the same thing you do in each window (.. that broadcasting is set to go to; mining+hauler configurations usually broadcast only to the miner and not the hauler.
FAQ: How do I broadcast only to certain windows, and leave out others?). Since there's so much mousing to do, Broadcasting mode is generally more useful in this game than Key Maps. Both can be used together though, with Key Maps (or, more specifically, Hotkeys) overriding broadcasting. (i.e. if broadcasting is enabled and you press W, it presses W in all. if W is mapped, and both broadcasting AND key maps are enabled, it does not press W in all unless that's what the map says to do).
That's pretty much it I think.